Bengaluru, NFAPost: A2A Pharmaceuticals has signed an agreement with Laxai Life Sciences Pvt. Ltd. to co-create SARS-CoV-2 Main Protease inhibitors for the treatment of COVID-19.
Under this collaboration, A2A designed the molecules using its proprietary computational AI-enabled drug discovery platform SCULPT, which are currently being synthesized and will be evaluated by Laxai. Both parties will collaborate in preclinical optimization and selection of lead candidates to enter the clinic.
“MPro is a very attractive drug target for COVID-19 due to its pivotal role in mediating viral replication and transcription as well as its druggability owing to a well-defined pocket and susceptibility to targeted covalent inhibitors demonstrated in recent structural information”, said Dr. Elena Diez Cecilia, program lead and director of BD and R&D strategy for A2A.
She added “We’re excited to embark on this collaboration with Laxai, combining our drug design expertise with Laxai’s vast drug discovery experience including chemical process R&D and GMP manufacturing. Combined, we are positioned to accelerate development to reach patients faster”
SARS-CoV-2 Protease Inhibitors Help Fight Spread of Covid-19
With this collaboration, A2A wants to put its technology and expertise to use to discover highly selective targeted inhibitors of SARS-CoV-2 MPro, as opposed to repurposing or vHTS efforts ongoing elsewhere, to design more efficacious and safer treatments.
Dr. Ram S. Upadhayaya, CEO Laxai Life Sciences, commented, “We are excited to collaborate with A2A on COVID-19 project. Laxai’s in-house technological capabilities truly compliments its intellectual prowess. This collaboration is an amalgamation of ahead-of-times thoughts; and the product can only be success!”
Dr. Raghava Reddy Kethiri, CSO Laxai Life Sciences, says, “the designed compounds have the potential to have broad-spectrum antiviral activity owing to the conserved active site residues of Mpro among multiple viruses in the supercluster, which includes coronaviruses and other related viruses that could emerge in future.”
About A2A Pharmaceuticals
A2A Pharmaceuticals is committed to the development of new therapeutic agents. A2A’s technology applies a proprietary therapeutic design methodology called SCULPT™, towards inhibiting protein-protein interactions.
About Laxai Life Sciences Pvt. Ltd.
LAXAI is a fully integrated contract research and development organization that delivers solutions in drug discovery, chemical process R&D, and GMP manufacturing for innovator pharmaceuticals.